Metadec
Unveiling the Benefits: ND & Vitamin D in Managing Vertebral Osteoporotic Collapse
Treatment of postmenopausal osteoporosis patients aims at a stimulation of the osteoblastic activity and improvement of calcium balance. Efficacy of two active drugs given for 12 months (1a calciferol- daily and nandrolone decanoate- 50 mg every 3 weeks) to improve the clinical, biochemical and densitometric condition of osteoporotic patients with established osteoporosis was evaluated in this double-blind trial.
Both regimens had a beneficial effect upon the clinical condition (pain, mobility), but ND was significantly more effective than vitamin D.
No recent vertebral collapse was observed in both groups.
An increase of bone mineral content was seen after 1 year of treatment with ND (5%), while those treated with vitamin D had a decrease of 2.5% per year of the bone mineral content.
Another beneficial effect of ND treatment was the significant decrease of the calcium/creatinine ratio. This could be largely caused by the increase of the creatinine excretion which, like the increase of serum creatinine, reflects the increased muscle mass. On the other hand, the calcium/creatine ratio was increased in the vitamin D treated group, because of the increased calcium absorption.
There was no significant difference in serum lipids in the nandrolone decanoate group in the given dose (50 mg nandrolone decanoate every 3 weeks).
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Ref: Bone Miner. 1994;27(3):209-17
QUALITY OF LIFE OF LEAN ELDERLY WOMEN AFTER A FEMORAL NECK FRACTURE
Protein-rich liquid supplementation in combination with nandrolone given for 6 months to lean elderly women after a femoral neck fracture positively affected LBM, ADL and HRQoL.
60 women patients in age group 70-92 years with BMI <24 kg/m2, were randomised into 3 groups:
PR group - received a protein-rich formula (200 ml/day, 20 g protein/day).
PR/N (combined therapy) group - prescribed the same formula but in combination with nandrolone decanoate (25 mg i.m./3 weeks)
C (control) group - received the standard treatment.
All patients received additional calcium (1 g) and vitamin D (400IE) daily for 6 months.
The patients were re-examined after 6 months and 12 months.
Nutritional support in combination with nandrolone given to lean female patients with femoral neck fractures treated with internal fixation had a significant positive effect on the activities of daily living (ADL) status, the health-related quality of life (HRQoL) and lean body mass during an intervention period of 6 months.
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Reference - Clinical Nutrition. 2004; 23:587–596.
NANDROLONE DECANOATE IMPROVES BONE QUALITY & QUALITY OF LIFE
Nandrolone decanoate increases the local production of growth factors in bone indicating an improvement of bone quality.
The therapeutic profile on bone of nandrolone decanoate is that of inhibitor of bone resorption with temporary increase in bone formation, followed by an absence of suppression of bone formation, indicating un-coupling of bone resorption and formation.
This results in an increase in bone mineral content at the proximal and distal radius, and in some patients at the lumbar spine.
Furthermore, nandrolone decanoate increases calcium balance and muscle mass, especially in the lower limbs, diminishes vertebral pain and increases the mobility of the spine, indicating that nandrolone decanoate does improve quality of life.
Nandrolone decanoate increases the local production of growth factors in bone indicating an improvement of bone quality.
A dose of 50 mg every 3 to 4 weeks is indicated in the treatment of osteoporosis in women with vertebral crush fractures or Pouteau Colles fractures, especially when they have low muscle mass, associated debilitating disease, and in patients with corticosteroid induced osteoporosis.
Injection of 50 mg of nandrolone decanoate resulted in peak nandrolone concentrations of 4.6 + 3.2 nmol/l after 24h. The mean plasma half life was 8 + 5 days.
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Ref: Clin Rheumatol. 1995;14(Suppl 3):32-9
Orthopaedic Applications of Nandrolone Decanoate
Nandrolone Decanoate proves to be a useful adjunct in the perioperative period for Orthopaedic Surgery.
Fracture repair in orthopaedic surgery often involves disuse muscle atrophy, which can delay recovery and impact outcomes.
Recent evidence suggests that anabolic androgenic steroids (AAS) in muscle may improve postoperative recovery and biological healing in specific clinical scenarios.
AASs have shown promise as a therapeutic tool in addressing musculoskeletal pain and disability, potentially augmenting biological healing after muscle injury, fracture repair, or rotator cuff repair, and improving postoperative recovery after ACL reconstruction or total joint arthroplasty.
Ref: J Am Acad Orthop Surg Glob Res Rev. 2022;6(1):e21.00156
The Impact of Nandrolone Decanoate Therapy on Bone Formation: A Comprehensive Review
Effects of Nandrolone Decanoate and Antiresorptive Therapy on Vertebral Density in Osteoporotic Postmenopausal Women
Comparing anabolic steroid nandrolone decanoate (ND) intramuscularly 50 mg every two or three weeks or antiresorptive therapy, 71 postmenopausal osteoporotic women were evaluated before and after treatment with either.
After a mean treatment period of 14 months, there was a mean increase of 20% in vertebral mineral density in the ND group, and no significant change in the antiresorptive therapy group.
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Ref: Arch Intern Med. 1989;149(1):57-60